Small molecule inhibition of the RNA exosome

Small molecule inhibition of the RNA exosome

Created 17 Mar 2026
•
Last activity 6 months ago
OverviewWork packagesDiscussions

We want to find small molecules or design biologics that interfere or stimulate the RNA exosome

A
Andrew Newman
lead researcher

Planetary Impact

We dont die as much

Methodology

We will use a screen with a fluorescent reporter that detects excess RNA from noncoding loci. Our drug treatments should reduce red fluorescence or increase green fluorescence depending on Exosome interference/stimulation respectively.

Work Package
Type
Status
CMC, Immunogenicity and Pre‑IND Strategy
technology development
TO DO
CNS In Vivo Proof‑of‑Concept
technology development
TO DO
MTR4 Allosteric Small‑Molecule Campaign
technology development
TO DO
ZCCHC8–MTR4 Interface Peptide Discovery
technology development
TO DO
Computational Platform and AI Design
technology development
TO DO
Assay Cascade and Validation Platform
technology development
TO DO

Discussions